Dr. Oz once asked the question on his titular talk show, “Could a diabetes drug cure obesity?” He was referring to semaglutide, better known as Ozempic and Wegovy, following a surge in demand for the medication.

Half a century of advancements in biomedical science paved the way for today's powerful weight-loss drugs like Ozempic—so what was that journey like for the scientists involved?

For significant weight loss, Zepbound may be the better option. If you have Type 2 diabetes and are looking for a dual approach to managing weight and the disease, Ozempic would likely be more suitable. Ultimately, talk to your doctor about health needs, financial situation and personal weight loss goals.

Research has shown there are plenty of perks of using a medication like Ozempic for weight loss. But, given that this is a drug, there are some potential downsides to consider, too. New research published in JAMA Network Open links GLP-1 receptor agonists—a class of medications that includes semaglutide medications like Ozempic and Wegovy—to a loss of bone density.