President Donald Trump’s ambitious agenda may be on the brink of a stinging setback in the House before it even gets started, offering a flashing warning sign about Speaker Mike Johnson’s ability to deliver other key White House priorities this year.

Against the odds, House Speaker Mike Johnson is trying Tuesday to muscle a Republican budget blueprint to passage, a step toward delivering President Donald Trump's “big, beautiful bill” with $4.5 trillion in tax breaks and $2 trillion in spending cuts over stiff opposition from Democrats — and even some Republicans.