The stage is set for the biggest regular season game in NFL history as the Detroit Lions take on the Minnesota Vikings on ...

Jennifer Lee Chan shares the latest injury report for Sunday's San Francisco 49ers vs. Arizona Cardinals game.

Detroit Lions offensive tackle Penei Sewell has been selected to his third consecutive NFC Pro Bowl roster, but the former Oregon Ducks unanimous All-American s ...

Detroit Lions offense excelled against San Francisco 49ers. Wayne Osmond, founding member of the Osmonds, is dead at 73 ...

San Francisco 49ers quarterback Brock Purdy exited Monday night's shootout with the Detroit Lions in the final two minutes, as the Niners were driving for a late touchdown to cut the Lions' lead to ...

Gibbs has taken the workhorse role in the first two games without Montgomery and run with the opportunity. He has back-to-back games with 100-plus rushing yards, and has continued to be a receiving ...

Detroit Lions safety Kerby Joseph was apparently unhappy about being passed over for this year's NFC Pro Bowl team, so he ...

This year, Detroit surged to a 12-1 record to start the season and has been one of the top teams in the NFL for months. Both Lions' losses -- a 20-16 setback against Tampa Bay and a 48-42 defeat at ...

Former Pittsburgh Steelers quarterback Josh Dobbs will start for the San Francisco 49ers in their game against the Arizona ...

San Francisco 49ers quarterback Brock Purdy will miss Sunday's season finale against the Arizona Cardinals due to a right ...

Listen in as 49ers tight end George Kittle was wired for sound during San Francisco's Week 17 matchup against the Detroit Lions, powered by Cisco.

Jameson Williams has game-breaking speed, but the Lions receiver has proven to be more than just a one-trick pony this season.