St. John's will try to defy the odds as a No. 2 seed when the NCAA Tournament 2025 gets underway. Second-seeded teams have been upset by No. 15 seeds three times in the last four years, most recently with No.

According to Bet MGM, the four championship favorites are, naturally, the four No. 1 seeds: Duke (+325), Florida (+325), Auburn (+400) and Houston (+600). The fifth choice on the board is No. 2 seed Alabama, sliding down significantly to +1600. Tennessee checks in at +1800, and every other option is +2500 or higher.

Who will win March Madness games this week? NCAA Tournament win probabilities, predictions, picks offer insight on first-round matchups, bracket.