Distribution of Ranvier nodes along myelinated axons is a critical determinant of conduction velocity, significantly influencing spike arrival timing and hence neural circuit function. The patterns of ...

However, the evidence supporting some of the conclusions remains incomplete, and further mechanistic studies are needed to clarify how miR-283 affects normal aging and influences exercise adaptations.

The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are ...

This important study shows how the relative importance of inter-species interactions in microbiomes can be inferred from empirical species abundance data. The methods based on statistical physics of ...

In the default model, the graph representing each individual enhancer can be arbitrarily complicated. To show how the ABC Score formula can arise from the default model, we need to impose the further ...

We highlight recent developments in eLife’s equity, diversity and inclusion framework and what steps we will be taking next.

Ecological network management provides key mechanistic knowledge on ecosystem degradation that links species- to ecosystem-level responses to global change, and emerging technological tools offer the ...

Bumblebees refine visual discrimination through selective and structured scanning, demonstrating a dynamic interplay between movement and perception in pattern recognition.

In pulmonary hypertension, a combination of metabolic and mechanical dysfunction leads to irreversible vascular damage.

Gut microbiota composition and sex hormones influence the immune response to methicillin-resistant Staphylococcus aureus gastrointestinal colonization in mice.

This useful study provides incomplete evidence that TANGO2 homologs, including HRG-9 and HRG-10, are not heme chaperones but play a role in cellular bioenergetics and oxidative stress homeostasis.

One notable missing feature in most ANN models is top-down feedback, i.e. projections from higher-order layers to lower-order layers in the network. Top-down feedback is ubiquitous in the brain, and ...