Throughout the course of multiple sclerosis, gradually progressive neurologic impairment can occur, which has been called ...

Tolebrutinib is an oral, brain-penetrant, and bioactive Bruton’s tyrosine kinase inhibitor that modulates peripheral ...

Enteral nutrition is defined as the provision of essential nutrients through an enteral tube to prevent or treat disease-related malnutrition in patients who are unable to consume adequate ...

The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have ...

A 79-year-old woman was evaluated for cough and weight loss. Chest imaging and thoracentesis findings confirmed the presence of an exudative right pleural effusion. A diagnosis was made.

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Treatment with fidanacogene elaparvovec, a recombinant adeno-associated virus (AAV) vector developed for the treatment of hemophilia B, led to sustained expression of the high-activity factor IX ...

Authors may complete the Presubmission Inquiry form below to learn about the suitability of proposed manuscripts or to propose review article topics. An NEJM Editor will generally respond by email ...

Tecovirimat is available for the treatment of mpox (formerly known as monkeypox) in Europe and the United States, on the basis of findings from efficacy studies in animals and safety evaluations ...

The National Academy of Medicine convened a workshop of experts and published a report that reviews the progress generative AI has achieved in health care and discusses future opportunities and ...

Atrial fibrillation is the most common cardiac arrhythmia that is encountered in clinical practice, with some 4.5% of the general population affected in the United States. It has been nearly 30 ...

A 4-year-old girl presented with a 3-day history of fever and dry cough. A chest radiograph showed a large, rounded opacity in the left lower lobe with subtle air bronchograms.